No issues but important thing is that you need to show them the reason for gap. It totally depends on you how you explain. It will not harm any of your reputation. It totally depends on how much good you are good in your domain or technology.
Nikhil Sood
@vivek : thanks...actualy i left IT so as to do a non IT business of my family...will this reason be ok or it wil prove 2 b a minus point , if i m gud in my domain?
Vivek Bhusan
This answer will sure make you in trouble. they will ask you more question on this like.
1) How we can trust you that you will not leave this job again
2) Why you want to join again.
Even if you are good at your domain the MNC or any company first check the trust and what kind of person you are.