Andhra Loyola College is managed and administered by the members of the Society of Jesus (Jesuits), a Catholic religious order, which has rendered signal service in the fields of education and service to humanity for over 450 years. The college was founded in December 1953 at the request of the Catholic bishops of Andhra Pradesh and began its academic sessions in July 1954. The college offers Intermediate (+2), Degree, and Postgraduate courses as well as conducts research programmes in collaboration with several reputable universities.

In 1988, the college was accorded the status of Autonomy for the Degree-level programmes by the University Grants Commission (UGC) in recognition of its excellent contribution to the cause of higher education. The degrees for both UG and PG programmes are awarded by Krishna University to which the college is affiliated.

In 2004, the college won the prestigious ‘College with Potential for Excellence’ (CPE) status from the UGC.

In September 2008, the college was re-accredited by the National Assessment and Accreditation Council (NAAC), Bangalore, with Grade A (CGPA 3.65 out of 4.00).